Lines in the sand have been drawn. I went to an infertility presentation on Monday with one of my friends/coworkers. The doctors presenting run the rival clinic to my own RE. It was depressing in the way that it reminded me how fragile the creation of life is and what we are truly embarking upon. My friend? Different scenario, set of circumstances, and she was invigorated. It was good for her.
I took away three questions/ponderings/ideas: 3 day transfer vs. 5 day transfer, egg quality (I know) and genetic testing.
The transfer difference is due to the assertion that the clinic that made the presentation was the first in our area to do 5 day blastocyst transfer. What this means is that the lab babysits the embryos for five days, until they reach a multi-cellular size and then transfer them back into the uterus, versus the typical three day babysitting the lab usually does. The reason that 5 day transfers are better than 3 day transfers are because doctors/scientists think that in a run-of-the-mill pregnancy conception occurs in the fallopian tubes and the embryo takes about five days to travel (and further develop) to the uterus and find a comfy spot to burrow in (implant). So 5 day blastocyst transfers might better mimic traditional timing. I need to find out which type of transfers my clinic does (because this presentation was made by a rival clinic).
Egg quality is kind of freaking me out. Again, typically and per past research, I should have nothing to worry about because the huge determining factor is age and I am relatively young (in this infertility game). What these doctors said in the presentation backs that theory up, but. But there are other factors besides FSH levels, such as history (my FSH and history are clear), AFC and some other count. And the doctors said that the reason human conception rates are so low (they are, at 15-20% chance of pregnancy each month, we have one of the lowest conception rate of any mammal – maybe not that bad, but when you don’t bring a dog in heat into the house – she always turns up full of puppies) are that a huge percentage of our eggs are incompatible with life, or genetically defective. The incompatibility/defect only increases with age, which is why pregnancy is possible after 40, but the movie stars are not using their own eggs. So, back to me – I should still be in the clear, right? IVF is a wonderful route to a baby, but it can also be an eye-opening diagnostic tool. Think about it: you’ve got the sperm and the eggs under a microscope and you are watching them get together and multiply. But you can see the two-headed sperm and the guys that seem to have no internal compass. And there are a few eggs you’re wondering about with cracked membranes and other irregularities. There are even a few embryos that formed, but now refuse to further develop. Look at everything you learned from sheer observation! The doctors stated that under that type of microscope, “unexplained” infertility (essentially, what we’re dealing with) often becomes an egg quality issue. Which isn’t incredibly worrisome in and of itself, but the AFC does concern me a bit. One of the slides had a picture of a healthy ovary and you’re supposed to have follicles with eggs waiting in the lining (AFC: antral follicle count). I’m not sure that I’ve ever seen that. I mean, my doctor can check and I’m not always sure what I’m looking at, but still. If it’s an egg quality issue, we’re screwed.
Now for the most controversial: genetic testing. When utilizing IVF, you can choose (for a couple extra $K) to have the embryos undergo PGD (preimplantation genetic diagnosis). I could delve into what PGD actually is, who it is useful for, and how often it is not used in the terrifying way that the general public thinks it is, but I won’t bore you with that or my views on PGD in general. I will recommend two books (if you don’t read my booklist on the other blog) if you are interested: The Match by Beth Whitehouse and The Baby Business by Deborah Spar – because heaven help you if you even attempt to discuss this issue without being well informed (did you catch that? I will never care for your ignorant, ill-informed opinion/advice/supposition). For us, my concern is CF (Cystic Fibrosis). I have a first cousin with a child who has CF, and while this child is amazing and active and his prognosis is good, this is still a disease with terrible realities. Rather than go through PGD with any of our embryos, we thankfully have another option – I can be tested to see if I am a carrier for CF. If I am, C can be tested. If C is, then we have some more decisions to make.
If there is a baby that comes from all of this madness, I wonder if he/she would even care or want to know the struggle/desire/love/money/science/medicine behind her/his conception and eventual birth. I’m sure it won’t matter to an infant or a ten-year-old, but is it either useful information or a sentimental story for a child about to get married or start a family of his/her own?
We have two videos that were shot while I was pregnant. C took them around nine weeks and they are me lying on the couch with the cutest Boris puppy draped across my midsection. The narrative is so sweet and genuine. Whether or not I ever torture myself by watching them is not the point; that they exist makes me feel less insane and possibly hopeful. This morning I briefly considered making another video. Something that puts a face, voice and story to this precipice we’re on. The concern and struggle and worry given a tone and wandering across my face. I’m not sure what it would be for exactly. Perhaps I need to check on motivation.
As for the lines drawn:
~I will ask my clinic which day they transfer embryos and do a little more research on the benefits of 5 day transfer vs. 3 day transfer. I doubt that there is enough evidence out there for me to switch clinics at this point in the game, not to mention building a new relationship with another RE when I am perfectly happy with my own RE.
~I’ll ask my RE if there are any additional tests we can do to determine egg quality, but outside of a disastrous result, the embryologist will probably see what I’m working with shortly after egg retrieval, which is too far into the process to change any protocols. There is a reason I compare IVF and ART procedures to Russian roulette.
~I will call my insurance company to price/see if they cover genetic testing for CF and then get tested. This is what will ease my worries. C does draw his line at PGD. My line is more a gray area full of what-ifs that I hope to never encounter.
- Posted from my mobile phone